Risk Factors for Autoimmune Diseases Development After Thrombotic Thrombocytopenic Purpura

Risk Factors for Autoimmune Diseases Development After Thrombotic Thrombocytopenic Purpura

Autoimmune thrombotic thrombocytopenic purpura (TTP) can be associated with other autoimmune disorders, but their prevalence following autoimmune TTP remains unknown. To assess the prevalence of autoimmune disorders associated with TTP and to determine risk factors for and the time course of the development of an autoimmune disorder after a TTP episode, we performed a cross sectional study. Two...

P2Y12 inhibition after thrombotic thrombocytopenic purpura remission

Thrombotic thrombocytopenic purpura after defibrotide therapy.

Thrombotic Thrombocytopenic Purpura after Percutaneous Coronary Intervention

Thrombotic thrombocytopenic purpura (TTP) is a rapidly progressive hematological syndrome defined by the pentad of thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, fever and renal dysfunction. TTP has been associated with major surgical procedures and specific medications. However, there is no known previously reported case in which acute TTP occurred after a percu...

Thrombotic thrombocytopenic purpura: reducing the risk?

von Willebrand factor (vWF) has a key role in initiating platelet aggregation, and thereby thrombus formation, that is dependent on its ability to form appropriately sized multimers. Ultralarge multimers promote the formation of the microvascular thrombi that are hallmarks of the life-threatening condition thrombotic thrombocytopenic purpura (TTP). In this issue of the JCI, Chen et al. show tha...